Alzheimer's disease DNA methylome of pyramidal layers in frontal cortex: laser-assisted microdissection study

Hernán Guillermo Hernández, Adrián Gabriel Sandoval-Hernández, Pablo Garrido-Gil, José Luis Labandeira-Garcia, María Victoria Zelaya, Gustavo F Bayon, Agustín F Fernández, Mario F Fraga, Gonzalo Arboleda, Humberto Arboleda
  • Epigenomics, October 2018, Future Medicine
  • DOI: 10.2217/epi-2017-0160

The first DNA methylation and laser assisted microdissection study in Alzheimer's Disease in humans

What is it about?

This is the first DNA methylation epigenetic study in the human epigenome through laser microdissection in the most common class of dementia (Late Onset Alzheimer Disease). Here we studied the pyramidal layer cells in the brain of Alzheimer's disease patients and controls.

Why is it important?

While interesting works in DNA methylation in AD have recently performed, none research has sub-selected sub-architectonic parts of the cerebral cortex of known vulnerability as the present work do by laser microdissection.

Perspectives

Hernán Guillermo Hernández

The information on DNA methylation patterns in Alzheimer's disease contributes to explain molecular modifications that are critical for the Pathogenesis of this disease.

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http://dx.doi.org/10.2217/epi-2017-0160

The following have contributed to this page: Hernán Guillermo Hernández