What is it about?
This is the first DNA methylation epigenetic study in the human epigenome through laser microdissection in the most common class of dementia (Late Onset Alzheimer Disease). Here we studied the pyramidal layer cells in the brain of Alzheimer's disease patients and controls.
Featured Image
Why is it important?
While interesting works in DNA methylation in AD have recently performed, none research has sub-selected sub-architectonic parts of the cerebral cortex of known vulnerability as the present work do by laser microdissection.
Perspectives
The information on DNA methylation patterns in Alzheimer's disease contributes to explain molecular modifications that are critical for the Pathogenesis of this disease.
Hernán Guillermo Hernández
Read the Original
This page is a summary of: Alzheimer's disease DNA methylome of pyramidal layers in frontal cortex: laser-assisted microdissection study, Epigenomics, October 2018, Future Medicine,
DOI: 10.2217/epi-2017-0160.
You can read the full text:
Resources
Researchgate web for the article
Researchgate web for the article "Alzheimer’s disease DNA methylome of pyramidal layers in frontal cortex: laser-assisted microdissection study"
abstract
Abstract for "Alzheimer’s disease DNA methylome of pyramidal layers in frontal cortex: laser-assisted microdissection study"
Contributors
The following have contributed to this page
