Functional and cognitive impairment, frailty in ESRD

What is it about?

In this systematic review we found that functional and cognitive impairment and frailty in patients reaching ESRD are highly prevalent and strongly and independently associate with adverse health outcomes after initiation of RRT or conservative kidney management. The associations were independent of calendar age and other known risk factors for poor outcome.

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Why is it important?

The results of this systematic review support the use of measurements of functional and cognitive impairment and frailty for risk stratification in patients reaching ESRD to guide shared decision-making about whether to start dialysis.