Acute Kidney Injury, Systemic Inflammation and Long-term Cognitive Function: ASSESS-AKI

What is it about?

Cognitive dysfunction is a well-known complication of chronic kidney disease, but it is less known whether cognitive decline occurs in survivors of acute kidney injury (AKI). We hypothesized that an episode of AKI is associated with poorer cognitive function, mediated, at least in part, by persistent systemic inflammation. Among 1420 matched participants with and without AKI, participants with AKI had worse cognitive decline at 3 years after hospitalization and this risk was mediated by plasma soluble tumor necrosis factor receptor-1 concentrations. This study highlights that AKI is associated with cognitive decline and soluble tumor necrosis factor receptor-1 concentrations appear to mediate a significant proportion of the risk of long-term cognitive impairment after AKI.

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