Molecular Signatures of Glomerular Neovascularization in a Patient with Diabetic Kidney Disease

What is it about?

The goal of the Kidney Precision Medicine Project is to create a molecular atlas of the kidney in health and disease in order to improve our understanding of the pathophysiology of chronic kidney disease and acute kidney injury. We present a case of a 66-year old woman with diabetes that underwent a protocol KPMP kidney biopsy. We describe the molecular findings obtained from interrogation of the kidney biopsy by some of the novel investigative techniques employed by the KPMP. We spotlight the finding of new blood vessel formation as one of the robust molecular signatures uncovered in the kidney as a correlate to the patient's clinical and pathological presentation. This correlation provides additional insights into the development of kidney disease in patients with diabetes and highlights the strength of the investigative techniques employed by the KPMP.

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