What is it about?
the administration of AEDs may cause dysfunctions in the communication between dams and their fetuses, and in the developmental thyroid-brain axis. These effects might depend on the concentration and period of administration of AEDs, and sex type and developmental period of animal species. Additional studies are necessary to clarify the potential associations with human health. Future examinations are needed to explore whether the effect of maternal AEDs on the developmental neuroendocrine system (THs-brain axis) and the cytokines markers play a role in modifying the signaling pathways related to the cellular proliferation and cell death during the perinatal period.
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Why is it important?
the administration of AEDs may cause dysfunctions in the communication between dams and their fetuses, and in the developmental thyroid-brain axis. These effects might depend on the concentration and period of administration of AEDs, and sex type and developmental period of animal species.
Perspectives
Additional studies are necessary to clarify the potential associations with human health. Future examinations are needed to explore whether the effect of maternal AEDs on the developmental neuroendocrine system (THs-brain axis) and the cytokines markers play a role in modifying the signaling pathways related to the cellular proliferation and cell death during the perinatal period.
Full Professor Ahmed R. G.
Division of Anatomy and Embryology, Zoology department, Faculty of Science, Beni-Suef University, Egypt.
Read the Original
This page is a summary of: Antiepileptic Drugs and Developmental Neuroendocrine Dysfunction: Every Why has A Wherefore, Archives of Medicine, January 2017, Scitechnol Biosoft Pvt. Ltd.,
DOI: 10.21767/1989-5216.1000244.
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