What is it about?
The use of synthetic estrogens as MHT and oral contraceptives resulted in various complications including myocardial infarct, stroke and cancers: breast and endometrial tumors in particular. These experiences supported the erroneous concept concerning the carcinogenic capacity of endogenous estrogen. In 2004, WHI investigators published that Premarin (an estrogen prepared from natural sources) used without synthetic progestogen, decreased significantly the breast cancer risk in postmenopausal women.
Photo by National Cancer Institute on Unsplash
Why is it important?
Toxic and carcinogenic effects of oral contraceptives (OCs) led to the recognition that the ethinylestradiol component of OCs is not a bioidentical estrogen but rather it is an endocrine disruptor. Historical examination of the controversial results of menopausal hormone therapy revealed that when the results showed improved bone density, beneficial lipoprotein content and decreased risk for cardiovascular diseases, the applied estrogen component was always Premarin instead of synthetic estrogens.
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This page is a summary of: Synthetic Estrogens Deregulate Estrogen Receptors Inducing Thromboembolic Complications and Cancer, December 2019, Bentham Science Publishers,
You can read the full text:
Amplified Crosstalk Between Estrogen Binding and GFR Signaling Mediated Pathways of ER Activation Drives Responses in Tumors Treated with Endocrine Disruptors
Inhibition of either liganded or unliganded activation of estrogen receptors deregulate the whole genomic machinery inducing genome wide disorders leading to chronic diseases including breast cancer
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