What is it about?

The use of synthetic estrogens as MHT and oral contraceptives resulted in various complications including myocardial infarct, stroke and cancers: breast and endometrial tumors in particular. These experiences supported the erroneous concept concerning the carcinogenic capacity of endogenous estrogen. In 2004, WHI investigators published that Premarin (an estrogen prepared from natural sources) used without synthetic progestogen, decreased significantly the breast cancer risk in postmenopausal women.

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Why is it important?

Toxic and carcinogenic effects of oral contraceptives (OCs) led to the recognition that the ethinylestradiol component of OCs is not a bioidentical estrogen but rather it is an endocrine disruptor. Historical examination of the controversial results of menopausal hormone therapy revealed that when the results showed improved bone density, beneficial lipoprotein content and decreased risk for cardiovascular diseases, the applied estrogen component was always Premarin instead of synthetic estrogens.


Discerning the carcinogenic effects of synthetic hormones and the anticancer effect of Premarin (with natural origin) supports author's well established principle: estrogen activated ERs are the principal regulators of the genomic machinery and DNA stability. This recognition may provide quite new possibilities in the treatment of all human diseases including cancer cure.

professor Zsuzsanna Suba
National Institute of Oncology Budapest

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This page is a summary of: Synthetic Estrogens Deregulate Estrogen Receptors Inducing Thromboembolic Complications and Cancer, December 2019, Bentham Science Publishers,
DOI: 10.2174/9789811404382119080005.
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