Synthetic estrogens are endocrine disruptors instead of activators of estrogen receptors.
What is it about?
The use of synthetic estrogens as MHT and oral contraceptives resulted in various complications including myocardial infarct, stroke and cancers: breast and endometrial tumors in particular. These experiences supported the erroneous concept concerning the carcinogenic capacity of endogenous estrogen. In 2004, WHI investigators published that Premarin (an estrogen prepared from natural sources) used without synthetic progestogen, decreased significantly the breast cancer risk in postmenopausal women.
Why is it important?
Toxic and carcinogenic effects of oral contraceptives (OCs) led to the recognition that the ethinylestradiol component of OCs is not a bioidentical estrogen but rather it is an endocrine disruptor. Historical examination of the controversial results of menopausal hormone therapy revealed that when the results showed improved bone density, beneficial lipoprotein content and decreased risk for cardiovascular diseases, the applied estrogen component was always Premarin instead of synthetic estrogens.
The following have contributed to this page: professor Zsuzsanna Suba
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