What is it about?
TRH shows CNS effects and endocrinological effects. Its CNS effects are applied for the treatment of wide range of neurological and psychiatric disorders. TRH mimetics which show strong CNS effects have been developing clinical trilals for the treatment of Parkinson's disease, Alzheimer's disease, epilepsy and depressant.
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Why is it important?
Many TRH mimetics have been developed in clinical trials, however only taltirelin has been launched as a treatment of spinocerebeller degeneration agent. Rovatirelin has been finished phase 3 clinical trials and now its clinical stage is preregistration.
Perspectives
In order to overcome the poor lipophilicity and permeability of biomembranes such as blood-brain barrier (BBB) of TRH, it will be needed to converting the chemical structure, prodrug approarch and using particle carrires. Accomplishing them, TRH and its mimetics are useful for the treatment of wide range of neurological and psychiatric disorders.
Naotake Kobayashi
Read the Original
This page is a summary of: Revaluation of Thyrotropin-Releasing Hormone and Its Mimetics as Candidates for Treating a Wide Range of Neurological and Psychiatric Disorders, October 2021, Bentham Science Publishers,
DOI: 10.2174/9781681089041121090006.
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