What is it about?
Endogenous estrogen activated estrogen receptors drive and control all cellular functions including glucose and lipid metabolism. Overeating or sedentary lifestyle results in excessive lipid deposition in adipocytes, disturbing their estrogen synthesis and estrogen receptor expression.
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Why is it important?
Considering the crucial role of estrogen signaling in human health, artificial inhibition of either liganded or unliganded ER activation causes deregulation and increases obesity associated diseases including risk for breast cancer.
Perspectives
Antiobesity and anticancer effects of estrogen treatment suggests: the improvement of estrogen signaling is the key to human health.
professor Zsuzsanna Suba
National Institute of Oncology Budapest
Read the Original
This page is a summary of: Circulating and Local Estrogen Concentrations are Protective against Breast Cancer in Obese Women, October 2015, Bentham Science Publishers,
DOI: 10.2174/9781681080765115040010.
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