What is it about?
The inhibitory effect of Tranexamic Acid (TXA) on γ-aminobutyric acid and glycine receptors of spinal dorsal horn neurons which leads to pain arousal, has been highlighted recently in animal studies. Such findings would elicit concerns about adverse effects of TXA as a routine agent used to reduce perioperative blood loss.
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Why is it important?
The utilization of TXA for adolescents and adults experiencing spinal corrective surgeries for spinal disfigurement has turned into the standard of care in several organizations.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to a surgical groups contacting me and ultimately to a greater involvement in its research.
Dr. Raham Hasan Mostafa
Ain Shams University
Read the Original
This page is a summary of: Increased Nociception Following Administration of Different Doses of Tranexamic Acid in Adolescent Idiopathic Scoliosis Surgery, The Open Anesthesia Journal, September 2018, Bentham Science Publishers,
DOI: 10.2174/2589645801812010061.
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