What is it about?
Tuberculosis (TB) is the second largest and deadly infectious disease caused by Mycobacterium tuberculosis . It is crucial to identify and find out the cure for this severe disease. Analysis based on structural and functional studies on ion channels and transporter proteins in M. tuberculosis responsible for its survival and virulence, are much needed. To assist the investigators better understand the context for these approaches, a summary of Ion-channels and transporter in Mtb including their putative function, its clinical manifestations, as well as host and bacterial responses during infection.
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Why is it important?
In context of Mycobacterium tuberculosis, there is not much development in drug discovery targeting ion channels but interaction of many blocker and inhibitors have been reported with Mtb ion channels and pumps. On the basis these studies, novel therapeutic agents like peptides, small molecules etc. can be designed.
Perspectives
It was great experience to write this review and had discussion with eminent scientists. Along with this studies, medicinal chemistry and electrophysiology-based studies are now very much needed to get lead for efficient cure of Tuberculosis.
MANISH DWIVEDI
Amity University Uttar Pradesh, Lucknow, India
Read the Original
This page is a summary of: Exploration of Ion Channels in Mycobacterium tuberculosis: Implication on Drug Discovery and Potent Drug Targets Against Tuberculosis, Current Chemical Biology, May 2020, Bentham Science Publishers,
DOI: 10.2174/2212796814666200310100746.
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