What is it about?
In this review, we summarized selected examples of the direct C-H activation/functionalization of pyridines. Classical SNAr, radical, or MCR reactions are powerful methods to access essential pyridine moiety with suitable functional groups. However, there is still an enormous gap in the demand to get to the functionalized pyridine with right regioselectivity in direct manner and the available methodology to supply it.
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Why is it important?
The coordinating ability of pyridine N poses a big challenge towards C-H functionalization on the pyridine ring. This review summarizes some of the recent methods towards this challenge
Perspectives
Pyridine has been one of the most ubiquitous hetero-aromatic moieties in pharmaceutical chemistry and it has enormous importance in a plethora of fields. From a synthetic chemistry standpoint, pyridine moiety has been used as directing group in C-H activation strategies to functionalize various rings.
Sushmita Roy
Tsinghua University
Read the Original
This page is a summary of: Recent Advances in Direct Pyridine C-H Activation Strategies, Current Catalysis, August 2022, Bentham Science Publishers,
DOI: 10.2174/2211544712666230104142809.
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