Syntheses, Characterization and Evaluation of Some 3-(benzothiazol-2-yl)- 2-(4-substituted phenyl) thiazolidin-4-ones as Antimicrobial Agents

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Some compounds were synthesized by four step reactions. First three steps involved synthesis of phenylthiourea, benzothiazol-2-ylamine and Schiff’s base srespectively. Finally, Schiff`s baseswere cyclized in the presence of thioglycolic acid to yield 4-thiazolidinone derivatives, characterized by spectroscopic and elemental analysis. Resulted compounds were evaluated for their in vitro antimicrobial activities against four bacterial and two fungal strains using agar diffusion method. All the compounds displayed good to moderate antimicrobial activity.

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