What is it about?
A significant proportion of drugs present in market, are poorly soluble. Formulation development of these drugs is also a demanding challenge. Nanosuspensions have revealed their potential to problems, associated with poorly soluble drugs.
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Why is it important?
Poor aqueous solubility is rapidly becoming the leading hurdle for formulation scientists working on the drug delivery system. While reduction of particle size has been employed in pharmaceutical industry for several decades, nanosuspension (nanosizing) can provide a further enhancement of dissolution rate and saturation solubility with improving bioadhesivity, bioavailability and safety of poorly soluble drugs since minimal presence of inactive additives is required in the formulation.
Perspectives
nanosuspension technology appears to be a unique and yet commercially viable approach to combating problems such as poor bioavailability that are associated with the delivery of hydrophobic drugs, including those that are poorly soluble in aqueous as well as organic media.
vijay agarwal
Read the Original
This page is a summary of: Nanosuspension Technology: A Strategic Approach for Poorly Soluble Drugs, Nanoscience & Nanotechnology-Asia, September 2013, Bentham Science Publishers,
DOI: 10.2174/22106812112029990001.
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