What is it about?
Comparative study of optimized nanoformulations of SEV, NPT methods by CCF design reveal that both methods produce spherical shape particles of nanosize, with homogenous distribution and good drug entrapment efficiency. Nanoprecipitation method is proved as the best optimized method, composed of nanoformulation of 1.0 % , w/v PLGA and 0.680 % , w/v Poloxamer exhibited mean particle size of 110.8 nm, entrapment efficiency of 71.62% and drug release 88.85 % at 12hrs, in comparison to solvent evaporation method.
Featured Image
Why is it important?
Central composite face-centered design presents a promising optimization tool for method and formulation of metformin loaded PLGA nanoformulations, but also a worthwhile option for economy of time and effort involved in complex development process of nanoformulations, for commercialization.
Perspectives
In a conventional approach, development of nanoformulation necessitate significant amount of time, effort and cost. The current investigation was aimed to study the impact of statistical central composite face centered (CCF) design on method and process optimization of metformin HCl (MH ) loaded poly (D,L-lactide-co-glycolide) (PLGA) nanoformulation.
Dr Bibhu Prasad Panda
Formurex Inc , Stockton , CA, USA
Read the Original
This page is a summary of: Impact of Statistical Central Composite Face Centered Design Approach on Method and Process Optimization of Metformin Hydrochloride Loaded PLGA Nanoformulation, Micro and Nanosystems, November 2017, Bentham Science Publishers,
DOI: 10.2174/1876402909666170817113542.
You can read the full text:
Contributors
The following have contributed to this page
