What is it about?

The body's function, in particular how it is regulated, has never been explained. There is recognition of 'physiological systems' i.e. networks of organs which function in a coherent manner, but there is not yet a precise understanding of what are these systems, which organs function in each of these systems, and what is their function. The author presents a coherent argument which illustrates that the body's pH is neurally regulated and that this in turn influences intercellular acidity, protein conformation, cell morphology and materially contributes to diabetes and other diabetic comorbidities.

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Why is it important?

This is important because it illustrates the function of the brain - it is a biological entity which continuously regulates the coherent function of the organ networks. This is a phenomena which cannot be explained by biology alone. It illustrates that emergent pathologies in each of the organs and systems materially influences the stable function of these systems and organs (including the brain).

Perspectives

This is important for several reasons: (I) it supports the scientific justification for the first mathematical model of the autonomic nervous system and physiological systems (developed by I.G. Grakov), (ii) it illustrates that stress influences brain function and hence the coherent function of the physiological systems, the organs in each system, the cells in each organ, and pathological onset in each of the cells, and (iii) that this is the mechanism for the dynamic relationship between the brain and viscera which is commonly known as the autonomic nervous system.

Mr Graham W Ewing
Mimex Montague Healthcare Limited

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This page is a summary of: pH is a Neurally Regulated Physiological System. Increased Acidity Alters Protein Conformation and Cell Morphology and is a Significant Factor in the Onset of Diabetes and Other Common Pathologies, The Open Systems Biology Journal, April 2012, Bentham Science Publishers,
DOI: 10.2174/1876392801205010001.
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