Interactions between the Bronchial Epithelium and Fibrocytes in the Pathogenesis of Airway Remodeling in Asthma

What is it about?

This article is an extensive review of the novel observations suggesting that bronchial epithelial cells of asthmatic patients may play a key role in the development and progression of persistent airflow obstruction through the release of substances which promote the recruitment, proliferation and local differentiation of circulating fibrocytes at every disease exacerbation.

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Why is it important?

The article concerns novel findings with important clinical and therapeutic implications. It is very informative and explicative, and helps understand even the most complex mechanisms of interaction between the bronchial epithelium and fibrocytes in asthma through the use of many schematic illustrations.