What is it about?
Here, we test the effects of a broccoli extract on human retinal cells under similar oxidative damage conditions seen in age-related macular degeneration. We showed that treatment of these cells with the extract can prevent cell death mediated by oxidative stress and can stimulate cell regeneration by increasing the redox enxzyme GSTM1 and by regulating selected metabolites.
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Why is it important?
This study reveals the potential of the broccoli extract to treat early stages of age-related macular degeneration to prevent disease progression or may be offered as a supplement to people at risk of this disease.
Perspectives
For the first time, we use high-throughput metabolomics to reveal of a broccoli extract may regulate protective effects and regeneration of human retinal cells. Thus, this article can also serve as a methodology reference.
Faith Kwa
RMIT University
Read the Original
This page is a summary of: L-Sulforaphane Confers Protection Against Oxidative Stress in an In Vitro Model of Age-Related Macular Degeneration, Current Molecular Pharmacologye, July 2018, Bentham Science Publishers,
DOI: 10.2174/1874467211666180125163009.
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