Nephroprotective and Nephrotoxicity N-Acetyl-L-Cysteine and Atorvastatin Imipenem Nephrotoxicity

What is it about?

A research on rats to show the effect of pre-administration of either NAC or atorvastatin to protect the kidneys from imipenem-induced nephrotoxicity, through their antioxidant effects.

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Why is it important?

Imipenem has played an important role in the treatment of broad-spectrum bacterial infection. However, nephrotoxicity due to imipenem remains an important clinical challenge. The study test the hypothesis stating that N-acetyl-L-cysteine (NAC) and atorvastatin possess a nephroprotective effect against imipenem-induced nephrotoxicity and show that pre-administration of either NAC or atorvastatin protects the kidneys from imipenem-induced nephrotoxicity, through their antioxidant effects.