Epidemiology of HBV and HCV related Hepatocellular carcinoma.

What is it about?

Hepatocellular carcinoma (HCC) is one of the most prevalent primary malignant tumor and accounts for about 90% of all primary liver cancers. Its distribution varies greatly according to geographic location and it is more common in middle and low- income countries than in developed ones especially in Eastern Asia and Sub Saharan Africa (70% of all new HCCs worldwide), with incidence rates of over 20 per 100,000 individuals.

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Why is it important?

Aim of this article it is to review key aspects of HCC epidemiology, especially highlighting the role of viral infection in the cancer progression, identifying important areas for future research.