What is it about?
The treatment with metformin is a good choice for women with PCOS. This work shows, using a murine model, that the nitric oxide system is involved in the regulation made by this drug, and oxidative stress is one of its targets.
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Why is it important?
The traetment with metformin is increasingly used and it is interesting and useful to know the mechanisms of action involved.
Perspectives
I hope that this, along with other works of mine and other authors, contribute to improving the reproductive health of women and that the knowledge of endocrine and immune systems, and of the oxidant/antioxidant balance, contribute to biomedicine and health in general.
Dr Carolina G Luchetti
Universidad de Buenos Aires
Read the Original
This page is a summary of: Metformin Prevents the Increase of Nitric Oxide and Lipid Peroxidation Induced By Dehydroepiandrosterone in Early Pregnant Mice, The Open Reproductive Science Journal, September 2013, Bentham Science Publishers,
DOI: 10.2174/1874255620130913002.
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