What is it about?
The study is about to understand the probable molecular mechanism of OCPs toxicity towards discovery of dysregulation of signaling pathway associated with differential gene expression and candidate transcriptomic set of markers in the pathophysiology of EOC in OCPs exposed population
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Why is it important?
This study provides the first evidence showing that differentially expressed genes and dysregulation of signaling pathways might be associated with significant level of OCPs exposure in ovary tissue of epithelial ovarian cancer patients. Moreover, significant correlation of these genes with OCPs revealed that OCPs exposure played vital role in dysregulation of related pathways in the etiology of EOC
Perspectives
I hope this article may help scientist to further explore a new field to study the biological factors with respect to organochlorine pesticides and their effect in the pathophysiology of cancer. This research has been done with the involvement of Department of Biotechnology, India pioneer research funding agencies and with a great scientists form the best Indian medical institute, AIIMS, New Delhi.
harendra shah
University of Delhi
Read the Original
This page is a summary of: Delineating Potential Transcriptomic Association with Organochlorine Pesticides in the Etiology of Epithelial Ovarian Cancer, The Open Biochemistry Journal, February 2018, Bentham Science Publishers,
DOI: 10.2174/1874091x01812010016.
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