What is it about?
Background &Aims: Cell-mediated immunity plays a critical role in viral clearance and disease progression during Hepatitis C virus (HCV) infection. Interleukin (IL)-12 is a cytokine that has been shown to be a potent antiviral cytokine. The aim of this work is to investigate the association of IL-12 B gene polymorphism with the progression of liver disease in chronic HCV patients.
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Why is it important?
Interleukin (IL)-12 is a cytokine that has been shown to be a potent antiviral cytokine. The aim of this work is to investigate the association of IL-12 B gene polymorphism with the progression of liver disease in chronic HCV patients.
Perspectives
A genotype presented more frequently in late stages of HCV chronically ill patients, while, CC genotype had no significant association with the severity of liver disease and had low frequency especially in late stages of liver disease
sherief Abd-Elsalam
Tanta University
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This page is a summary of: Evaluating the Role of Interleukin-12 B gene polymorphism in prediction of disease progression in patients with chronic hepatitis C virus infection., Infectious Disorders - Drug Targets, June 2017, Bentham Science Publishers,
DOI: 10.2174/1871526517666170606103533.
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