What is it about?
The use of cell-penetrating peptides as drug delivery system along with doxorubicin is a strategy to reduce its side effects. We have shown that poly-L-arginine can increase the cytotoxicity and cellular uptake of doxorubicin in DU145 cells through induction of necrosis.
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Why is it important?
Our finding shows that the use of poly-L-arginine maybe a strategy to overcome the side effects of doxorubicin by improving its therapeutic index through enhancing cellular uptake.
Perspectives
I hope this article encourages others to do some researches for improving the doxorubicin drug delivery system.
Razieh Jalal
Ferdowsi University of Mashhad
Read the Original
This page is a summary of: Poly-L-arginine: Enhancing Cytotoxicity and Cellular Uptake of Doxorubicin and Necrotic Cell Death, Anti-Cancer Agents in Medicinal Chemistry, January 2019, Bentham Science Publishers,
DOI: 10.2174/1871520618666180412114750.
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