What is it about?
Flubendazole (FLU) has a significant anti-migratory effect in intestinal cancer cell SW480 and its lymph node metastatic cells SW620. FLU decreases the expression of some proteins involved in metastatic processes and inhibits activation of NF-κB.
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Why is it important?
Our findings show that the anthelmintic benzimidazole drug Flubendazole (FLU) acted as effective anti-adhesive agent in SW480 adenocarcinoma colon cells. In cells lymph node metastatic SW620 cells, significant anti-migratory effect of FLU was manifested. In addition to inhibition of NF-κB p65 activation and decreased expression of the markers involved in these processes in metastatic cells, FLU caused reduction of migration by distinct mechanism, yet to be further explored.
Perspectives
This article was created based on long term coperation between two research group and conclusions follow on previous results and studies and could contribute to understanding mechanism of action of flubendazole in selected colon cancer cells.
Veronika Skarková
Charles University
Read the Original
This page is a summary of: The Effect of Flubendazole on Adhesion and Migration in SW480 and SW620 Colon Cancer Cells, Anti-Cancer Agents in Medicinal Chemistry, November 2018, Bentham Science Publishers,
DOI: 10.2174/1871520618666171213141911.
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