What is it about?
New 6,8-dibromo-2-(4-chlorophenyl)-quinazoline-sulphonamide hybrids and some Schiff´s base analogs have been designed and synthesized. All new derivatives were screened in vitro against MCF7, HCT116 and HEPG2 cell lines. Compounds IV, IXd and IXf exerted powerful cytotoxic activity with low IC50. The best active derivatives were screened for their inhibitory activity against EGFR-TK. As expected, compounds IV, IXd and IXf exhibited powerful EGFR TK inhibitory activity.
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Why is it important?
The present work led to the discovery of new cytotoxic compounds having quinazoline pharmacophore.
Perspectives
I hope that my paper help to discover new antitumor active compounds against different types of cancers which may become a great help for humanity in cancer treatment.
Marwa Ahmed
Read the Original
This page is a summary of: Synthesis and Evaluation of Some Dibromoquinazoline-sulphonamide Hybrids and some Schiff´s Base Analogs for their Cytotoxic Activity, Anti-Cancer Agents in Medicinal Chemistry, November 2017, Bentham Science Publishers,
DOI: 10.2174/1871520617666170327154409.
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