Activating mutations affecting ERs have key roles in genome stabilization and tumor response
What is it about?
Activating mutations affecting ERs play key roles in both the machinery of genome stabilization of healthy cells and the restoration of altered genetic pathways of DNA-repair in tumor cells.
Why is it important?
Results of genetic studies on both estrogen- and antiestrogen-treated tumors were reanalyzed and associations among ER-blockade, compensatory restoration of ER-signaling and clinical behavior of cancers were investigated.
The following have contributed to this page: professor Zsuzsanna Suba
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