What is it about?
This work focused on the identification and optimization of formulation and process variables affecting the characteristics of nanosuspension, using the Esomeprazole magnesium as a drug candidate. Formulation factors evaluated were ratio of stabilizers to drug and ratio of anti-solvent to solvent, whereas process parameters were ultrasonication time, power input, stirring speed and process temperature effect. The test revealed that ratio of the stabilizer to drug and ratio of anti-solvent to solvent has the significant effect on zeta potential and particle size, whereas different process parameters have significant effect on the particle size and their distribution.
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Why is it important?
Optimization of nanosuspension using the anti solvent precipitation ultrasonication method is a complex process since it includes a large number of factors that affects the nanosuspension characteristics. This study helped in identifying the certain formulation and process parameters
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This page is a summary of: Investigation of Formulation and Process Parameters for the Production of Esomeprazole Nanosuspension by Anti Solvent Precipitation Ultasonication Technique, Current Nanoscience, November 2013, Bentham Science Publishers,
DOI: 10.2174/15734137113099990079.
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