What is it about?
Development and validation of simple, rapid and cost effective stability-indicating RP-HPLC method for the assay of Carvedilol (beta blocker) in pure and tablet dosage form. The proposed method has been validated as per the guideline of ICH and is found to be highly accurate, precise and robust for the assay of CD in both pure and tablet dosage forms. The forced degradation studies showed that the degradation products do not interfere with the peak of CD
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Why is it important?
The test method has been compared with the official USP methods for pure and tablet dosage forms. The developed method is found to be statistically equivalent to the official methods. The proposed single method can be applied with high accuracy and precision to the analysis of Carvedilol in both pure and pharmaceutical dosage forms as compared to the official USP methods, which are different for both pure and dosage forms of Carvedilol.
Perspectives
It was a great experience on working this topic which involves a new method development followed by forced degradation studies to evaluate either it is stability indicating or not and lastly comparison with the official USP method. The main objective was to develop simple and economical method which included a trouble-free preparation of mobile phase with rapid detection of the active drug. Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. They have always supported me by giving helpful ideas and brilliant suggestions.
Anam Khan
Baqai Medical University
Read the Original
This page is a summary of: Development and Validation of a Stability-Indicating HPLC Method for the Assay of Carvedilol in Pure and Tablet Dosage Forms, Current Pharmaceutical Analysis, January 2018, Bentham Science Publishers,
DOI: 10.2174/1573412913666170525122146.
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