What is it about?
The present study is carried out to screen the anticholinesterase effect of the total alkaloids of L. sativum seeds and other plants, and studied the ability of Lepidine B to inhibit AChE, BuChE, BACE and MAGL. and the main interactions in inhibitor-enzyme complex.
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Why is it important?
While there is no cure for Alzheimer's disease or a way to stop or slow its progression, Lepidine B and E were suggested in this paper as drugs that may help treat symptoms.
Perspectives
The docking study indicate that Lepidine B is a promising anti-AD drug and might become a drug candidate to prevent Alzheimer's disease due to its multiple roles as potent inhibitor for AChE, BuChE, BACE and MAGL, also inhibitor for Aβ fibrillogenesis. No previous results about the inhibitory effect Lepidine B on the AChE, BuChE, β secretase and monoacylglycerol lipase have been reported.
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Read the Original
This page is a summary of: Lepidine B from Lepidium sativum Seeds as Multi-Functional Anti- Alzheimer’s Disease Agent: In Vitro and In Silico Studies, Current Computer - Aided Drug Design, July 2021, Bentham Science Publishers,
DOI: 10.2174/1573409916666200302120305.
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