What is it about?
In vitro antibacterial inhibition and little DNA cleavage potential of the compound explored. We extended our study to explore the inhibition mechanism by conducting molecular docking, ADMET and molecular dynamics analysis by using Schrödinger. TML-Hydroxy showed the moderate inhibition against Mycobacteria tuberculosis with MIC 25.00 μg/mL.
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Why is it important?
this study would pave the way for future development of more effective analogs for applications in medicinal field.
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This page is a summary of: In silico appraisal, Synthesis, Antibacterial screening and DNA cleavage for 1,2,5-thiadiazole derivative, Current Computer - Aided Drug Design, February 2019, Bentham Science Publishers,
DOI: 10.2174/1573409915666190206142756.
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