What is it about?
From a medicinal chemistry point of view, ST7612AA1 is a HDAC inhibitor having a thiol as Zinc Binding Group. The same is present in the structure of Romidepsin (Istodax®), which is a natural product, i.v. administered. ST7612AA1 is a synthetic product, very powerful, low toxicity compared with all other HDAC inhibitors already FDA approved, active on different tumors and orally administered.
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This page is a summary of: Synthesis of ST7612AA1, a Novel Oral HDAC Inhibitor, via Radical Thioacetic Acid Addition, Current Bioactive Compounds, October 2016, Bentham Science Publishers,
DOI: 10.2174/1573407212666160504160556.
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