What is it about?

The article provides an overview of modern concepts of induced sputum analysis and a description of the methodology and protocols for the collection of induced sputum in adults and children. This paper describes the cellular composition of induced sputum in healthy people and in patients with asthma in detail, analyses the significance of the sputum eosinophil count as a prognostic and diagnostic criterion and the role of other cells, such as neutrophils, macrophages, basophils. In this article, we review a number of asthma biomarkers of inflammation and remodeling of the airways in asthma, which can be determined in sputum (anaphylatoxin C3a, clusterin, periostin).

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Why is it important?

We summarize recent data about asthma phenotypes and describe the possibilities of using induced sputum analysis as a diagnostic and therapeutic tool for personalized anti-inflammatory therapy for asthma.


The analysis of induced sputum in asthma may prove to be a useful clinical tool in the assessment of underlying inflammation as part of the disease process and monitoring of therapeutic responses. The high informativeness of the induced sputum analysis, its safety, and the possibility of repeatability allow the recommendation of this induced sputum analysis as a diagnostic tool for asthma, including children.

Professor Vasilii Sergeevich Chulkov
Yaroslav the Wise Novgorod State University

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This page is a summary of: The Clinical Relevance of Differential Cell Counts in Induced Sputum and its Relationship with Various forms of Asthma, Current Respiratory Medicine Reviews, May 2021, Bentham Science Publishers,
DOI: 10.2174/1573398x17666210611091246.
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