What is it about?

Piperine is a component of the spice black pepper. It inhibits the process of any non-food material including drugs to be thrown out of the system and thus enhances their effect. Therefore if black pepper is taken before taking the medicine , specially anticancer drugs , their activity increases multiple times. This paper shows many other piperine analogues which are expected to have more activity .Workers in this field may synthesize these and test in vivo.

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Why is it important?

This paper suggests that the potency of many drugs specially anticancer drugs can be enhanced by taking these along with piperine, an alkaloid present in black pepper.

Perspectives

A simple suggestion is indicated in this paper that taking piperine (a component of black pepper) along with oral drugs can enhance their bioavailability and therefore potency. Also it gives a message toworkers in the field of medicinal chemistry to prepare the suggested compounds and test them in vivo.

Professor Krishna Misra
Indian Institute of Information Technology Allahabad

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This page is a summary of: Study of Some Piperine Analogues on Drugs Efflux by Targeting P-glycoprotein, an in silico Approach, Letters in Drug Design & Discovery, October 2016, Bentham Science Publishers,
DOI: 10.2174/1570180813999160830102312.
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