What is it about?
A facile one-pot multi-component synthesis of corticosteroid thiopyran derivatives, which possess anti-bacterial activity. Excellent yields of the products, and non-chromatographic purification are some of the main advantages of this protocol.
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Why is it important?
Keeping in mind the wide range of applications of corticosteroids and thiopyran, herein we intend to develop a simple and efficient strategy to synthesize steroidal thiopyran derivatives starting with different commercially available corticosteroids and study their biological properties.
Perspectives
To achieve our aim, we employed a one-pot multi-component synthesis of steroidal thiopyran derivatives by the reaction of corticosteroids, malononitrile, and carbon disulphide in the presence of triethylamine as a catalyst
Dr Shafiullah
Aligarh Muslim University
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This page is a summary of: Multi-Component One-Pot Assisted Synthesis, Anti-bacterial Capabilities, and Scanning Electron Microscopy of Novel Corticosteroid Thiopyran, Current Organic Synthesis, June 2021, Bentham Science Publishers,
DOI: 10.2174/1570179417666201218164112.
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