A Digital Signal Processing-Based Bioinformatics Approach to Identifying the Origins of HIV-1 Non B Subtypes Infecting US Army Personnel Serving Abroad

What is it about?

Amongst the HIV-1 categories available are B and non-B clades. The B isolates are usually found in Europe and America. However, two non-B isolates, 98US_MSC5007 and 98US_MSC5016 have been identified amongst American soldiers. Integration of these non-B isolates into a community with predominantly B strains, and subsequent procreation will result in diverse sequence alignment, physio-chemical and structural properties diversity and cross-typing. Failed HIV/AIDS treatment has been associated with high rate of replicability as well as resistance resulting from increase in protein sequence mutability. A good knowledge of the evolutionary roadmaps of HIV will proffer solution to its sequence mutability and resistance. In this study, the origin of the two non-B HIV-1 isolates found US army is identified with the aim of re-routing them so as to minimize the risk of diversity, cross-typing and associated reduced susceptbility.

Featured Image

Why is it important?

This study is intended to identify the origin of the two non-B HIV-1 isolates found US army and re-routing them to their various countries of origin with the aim of minimizing the risk of diversity and cross-typing, hence the attendant resistance.