What is it about?
This is about Structure-based Design of Synthetic and Natural Sourced Inhibitors Against Zika Viral Targets.
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Why is it important?
As the Zika is a worldwide pandemic dreadful viral transmission through Aedes mosquito vector. It can cause fever, joint pain or rash, and conjunctivitis. Pregnant mothers suffering from Zika viral infection may have fetal abnormalities due to severe neurological problems which can be characterized by microcephaly along with Guillain-Barré syndrome, issuing ZIKV a major public health concern as declared by the WHO. Therefore, it is a big panic for scientists to destroy the virus completely by generating potent inhibitors. For the purpose, various Zika viral targets were explored by structure-based design in the present review in connection with the discovery of various synthetic and natural sourced inhibitors against Zika virus. The structure-based drug design tools such as x-ray crystallography and molecular docking reported various co-crystallized ligands and Zika virus inhibitors. Such inhibitors could further be modified for the design of highly active leads to combat Zika virus utilizing chemoinformatics modules.
Perspectives
As the Zika is a worldwide pandemic dreadful viral transmission through Aedes mosquito vector. It can cause fever, joint pain or rash, and conjunctivitis. Pregnant mothers suffering from Zika viral infection may have fetal abnormalities due to severe neurological problems which can be characterized by microcephaly along with Guillain-Barré syndrome, issuing ZIKV a major public health concern as declared by the WHO. There is hardly any FDA approved anti-Zika viral drugs available. Therefore, it is a big panic for scientists to destroy the virus completely by generating potent inhibitors. For the purpose, various Zika viral targets were explored by structure-based design in the present review in connection with the discovery of various synthetic and natural sourced inhibitors against Zika virus. The structure-based drug design tools such as x-ray crystallography and molecular docking reported various co-crystallized ligands and Zika virus inhibitors. Such inhibitors could further be modified for the design of highly active leads to combat Zika virus utilizing chemoinformatics modules.
Assistant Professor MOHIT KUMAR
Division of Pharmaceutical Chemistry, VCTE Bijnor
Read the Original
This page is a summary of: Current Breakthroughs in Structure-based Design of Synthetic and Natural Sourced Inhibitors Against Zika Viral Targets, Current Topics in Medicinal Chemistry, December 2018, Bentham Science Publishers,
DOI: 10.2174/1568026619666181120125525.
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