What is it about?
Some medicines don't dissolve well in water, which makes it hard for our bodies to absorb them when taken by mouth. To help with this, scientists use a special technique called a self-emulsifying drug delivery system (SEDDS). It's like mixing oil and water in a way that creates tiny droplets, making the medicine easier to absorb. In this research, role of surfactants molecules to help oil and water mix is being described. The effect of length of the tail on these molecules (like how long a string is) affects how well and how quickly the mixture forms tiny droplets. The results showed that changing the length of these tails changes absorption of drug. Shorter or longer tails leads to self emulsifying system with varied effectiveness and stability.
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Why is it important?
Nearly 40% of drugs are poorly soluble in water water. This research helps design lipid based syatem with optimized surfactant concentration with minimal side-effects and maximum effectiveness.
Perspectives
This publication offers more than just scientific data—it provides formulation insight with real-time data for lipid based formulations. It provides a deep overview on role of lipid based drug delivery system and effect of surfactant chain length on the drug delivery, approaching more efficient, patient-centered, and sustainable pharmaceutical solutions.
SHAILENDRA CHOUHAN
Faculty of Pharmacy, Medicaps University
Read the Original
This page is a summary of: Effect of Surfactant Chain Length on Emulsification Dynamics of Self
Emulsifying Formulation of Poorly Soluble Drug, Current Drug Delivery, October 2022, Bentham Science Publishers,
DOI: 10.2174/1567201818666210727092639.
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