What is it about?
Warfarin is one of the most commonly used oral anticoagulants in the clinic. Although effective, warfarin has limitations that complicate its use. The shortcomings result from unsatisfactory pharmacodynamics of the drug and lead to significant fluctuations of active concentration of the drug in blood plasma. We showed that silica matrix in the sol-gel derived warfarin-silica composite promotes the drug release without lag effect and according to zero order kinetics irrespective to the drug location in gastrointestinal tract.
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Why is it important?
Our studies demonstrated that it is possible to create new silica-based formulation of warfarin with predictable kinetic behavior in biological medium. The formulation can lead to increase of patient comfort and/or improve compliance.
Perspectives
The studied warfarin-silica composite can serve as a platform for further development of novel formulation of the drug with improved pharmacological and consumer properties
Elena Parfenyuk
Read the Original
This page is a summary of: Sol-gel Derived Warfarin – Silica Composites for Controlled Drug Release, Current Drug Delivery, July 2017, Bentham Science Publishers,
DOI: 10.2174/1567201813666161021103714.
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