Hyaluronan-in drug delivery

What is it about?

Hyaluronan (HA), a glycosaminoglycan, is a key extracellular matrix (ECM) component, whose expression is usualy increased in different neoplasmatic tissues. , HA binds to its specific cell-surface receptors. Moreover, HA binding can be followed by receptor-movement to interior of the cell. In this concept HA fragments can be utilized as specific targeting carriers for efficient and safe drug delivery in cancer. I

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Why is it important?

We critically and in depth discuss aspects of HA metabolism in cancer and recent developments of its utilization in cancer therapy.

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