What is it about?
The article talks about the crystal structure of glucokinase. Furthermore, mechanism of glucose regulation, and impact of gene modification was discussed. At last, it talks about how inhibition of its regulatory protein will activate the enzyme.
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Why is it important?
The article defines which of a molecule's conformational options will be adopted in its crystal structure and how the crystal structure will determine the active and inactive state.
Perspectives
The article will give more insight into the structure and activity of the protein Also the article discusses how new therapy method of inhibiting the regulatory protein will help in treating diabetes.
Dr. Ajita PAliwal
Galgotias University
Read the Original
This page is a summary of: Current Insight on the Role of Glucokinase and Glucokinase Regulatory
Protein in Diabetes, Mini-Reviews in Medicinal Chemistry, April 2024, Bentham Science Publishers,
DOI: 10.2174/1389557523666230823151927.
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