What is it about?

Nitrogen and sulphur based heterocyclic molecules have gained significant attention owing to their broad spectrum pharmacological profiles. Thiazine is one of such promising scaffolds which has been widely utilized in the synthesis of compounds that possess interesting biological profile including anti-proliferative, anti-bacterial, antipsychotic, analgesic, anti-inflammatory, antifungal and antiviral activities. The current review focuses on the chemistry of thiazine and its derivatives along with potential pharmacological activities reported for these in scientific literature. Multifaceted pharmacological profile of thiazine derivatives provides new aspects for the design of superior medicinally active agents.

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Why is it important?

Thiazine nucleus has been many times reported as a key structural component of the medicinal chemistry. Various molecules possessing thiazine nucleus have been explored by researchers from time to time in order to obtain medicinally potent molecules. The structure activity relationship study of this moiety has shown promising pharmacological activity against various molecular targets. Further investigations of new thiazine based lead may yield more potent and target specific drug molecules. Thus, thiazine nucleus is considered interesting and important privileged substructure for the researchers of medicinal chemistry community. The compiled information of thiazines in this review may help in designing more potent substituted thiazine derivatives for their various existing or identified pharmacological activities.


This publication will benefit all the medicinal chemist who are working on thiazine scaffold and trying to find out its medicinal value.

Om Silakari

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This page is a summary of: Key Updates on the Chemistry and Biological Roles of Thiazine Scaffold: A Review, Mini-Reviews in Medicinal Chemistry, September 2018, Bentham Science Publishers,
DOI: 10.2174/1389557518666180416150552.
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