What is it about?
Centrosomes are the key regulating element of cell cycle progression. Aberrations in their functional mechanism leads to several cancer related disorders. Although genomic studies in the field of centrosome have been extensively carried out, with the lack of structural conformation, the proteomic analysis of pathological genetic mutation is still a challenging task.
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Why is it important?
Application of these highly efficient platforms in centrosomics studies will be a novel approach to develop an efficient drug therapy for the treatment of their dysfunction disorders.
Perspectives
Several computational algorithms and high range force fields are used to design the 3D structure conformation of proteins, which has now become the leading platform for in-silico drug discovery approaches.
Dr Rituraj Purohit
CSIR-Institute of Himalayan Bioresource Technology
Read the Original
This page is a summary of: Role of Centrosome in Regulating Immune Response, Current Drug Targets, April 2014, Bentham Science Publishers,
DOI: 10.2174/1389450115666140321120315.
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