What is it about?
Kuan Xiong aerosol (KXA) is a Chinese herbal compound used to regulate qi-flowing to relieve pain and improve angina. However, only a few pharmacological studies on this traditional Chinese medicine preparation have been reported to confirm these activities.
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Why is it important?
It was found that KXA reduced ECG ST-T waves and serum cTn-T in the rabbit AMI model, protecting myocardial tissue from fracturing and loss of myocardial fibers and inhibiting inflammatory cell infiltration, cavitation degeneration, and karyopyknosis of the myocardial matrix. Furthermore, the administration of 0.215, 1.075, and 2.150 mg.mL-1 of KXA resulted in significant relaxation of the aortic rings at a rate of 69.63 %, 90.14 %, and 118.72 % (p < 0.01) in the untreated ones, and a second shrinkage ratio of 20.17 %, 4.29 %, and 4.54 % (p < 0.01) in the untreated ones, respectively.
Perspectives
Kuanxiong Aerosol is a Chinese herbal medicine compound preparation, which is an empirical formula used to treat angina in clinical from an old time in China. Although this aerosol has been used for a certain time, the relevant pharmacological study is rarely to be found. We hope this Chinese herbal medicine compound preparation could be concerned ,and more related pharmacology and mechanism would be researched.
xia liu
Zhejiang Academy of Traditional Chinese Medicine
Read the Original
This page is a summary of: Study on the Effects of Kuanxiong Aerosol on the Isolated Artery and
Rabbits Acute Myocardial Ischemia Model, Combinatorial Chemistry & High Throughput Screening, May 2022, Bentham Science Publishers,
DOI: 10.2174/1386207324666210811142312.
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