What is it about?
Glycation (non-enzymatic chemical alterations) of proteins changes the way they fold and interact in the body, disrupting key biochemical processes and creating new, potentially toxic, behavior. While some biomedical research fields, such as diabetes and various autoimmune disorders, have recognized the importance of glycation for some time, the extent to which it impacts numerous other pathologies such as endocrine and neurological disorders is only now coming under intense scrutiny.
Featured Image
Why is it important?
The emerging scrutiny of glycation as a key pathological contributor to neurodegenerative and neuropsychiatric disorders may open up crucial new insight and opportunities for biomedical intervention. These developments may provide the key to unlocking cures for some of the most intransigent diseases, such as Alzheimer's and ALS.
Perspectives
Although this mini-review is written as a general perspective of relevance to a broad range of disease, the chemistry and structural biology surrounding glycation has provided key clues employed by our biotech startup, TheraPeptics, in the identification and characterization of very specific novel neuromedical drug targets.
Dr Gerald H Lushington
LiS Consulting
Read the Original
This page is a summary of: Protein glycation: An old villain is shedding secrets, Combinatorial Chemistry & High Throughput Screening, July 2019, Bentham Science Publishers,
DOI: 10.2174/1386207322666190704094356.
You can read the full text:
Contributors
The following have contributed to this page
