What is it about?
Review article reporting the neuroprotective function of astrocytes in the brain, involvement of astrocyte dysfunction in neurodegeneration, and experimental approaches to dopaminergic neuroprotection
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Why is it important?
Although treatments to improve the motor disability in Parkinson's disease are being assessed at present, the main challenge remains that is the development of neuroprotective or disease-modifying treatments. Therefore, it is desirable to find approaches that can inhibit the progression of dopaminergic neurodegeneration.
Perspectives
Astrocytes play an important role in the maintenance of the neuronal environment and exert neuroprotective effects. In addition, astrocyte dysfunction increases the susceptibility of neurons to cytotoxicity. We have reported neuroprotective approaches in parkinsonian models in various studies targeting astrocytes. The review discusses new promising therapeutic strategies to prevent dopaminergic neurodegeneration in Parkinson's disease.
Ikuko Miyazaki
Okayama Daigaku
Read the Original
This page is a summary of: Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease, Current Pharmaceutical Design, January 2018, Bentham Science Publishers,
DOI: 10.2174/1381612823666170710163731.
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