Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall

Katariina Öörni, Satu Lehti, Peter Sjövall, Petri T. Kovanen
  • Current Medicinal Chemistry, May 2019, Bentham Science Publishers
  • DOI: 10.2174/0929867325666180530094819

A review article describing why chylomicrons and VLDL are harmful

What is it about?

In this article we summarize research findings indicating that chylomicron and VLDL remnants, the triglyceride-rich lipoprotein species in circulation, can accumulate in the arterial wall. There they have the potential to induce local inflammation, lipid accumulation, and lead to formation of atherosclerotic lesions. The processes are similar to those happening with LDL, the cholesterol-carrying lipoproteins.

Why is it important?

The role of triglyceride-rich lipoproteins in the development of atherosclerosis has recently emerged because of clinical findings. We wanted to describe the biochemical mechanisms behind the clinical findings.

Perspectives

Dr Katariina Öörni
Wihuri Research Institute

The topic was timely and directly related to our work. Therefore, it was a pleasure to write the article together with the co-authors.

Read Publication

http://dx.doi.org/10.2174/0929867325666180530094819

The following have contributed to this page: Dr Katariina Öörni and Petri Kovanen