Strategies to improve the escape of gene delivery platforms from endosomes

What is it about?

Endosome entrapment is a key barrier to the success of non-viral gene delivery systems. This review details various methods that have been investigated to improve the escape of delivered genes/oligonucleotides from endosomes following their cellular uptake.

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Why is it important?

Endosome escape is a very important barrier to the success of non-viral gene delivery systems. This review provides important examples of successful approaches to improve the endosome escape of genes. This information is essential for the successful development of non-viral gene delivery systems.

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