What is it about?

A series of novel acridine derivatives were synthesized and evaluated for their in vitro antiproliferative activities against K562 and K562/ADM cells. Some of these compounds showed superior MDR-reversing activities than Amsacrine. Several compounds were examined for their ability to increase the accumulation of rhodamine 123 in K562 and K562/ADM cells.

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Why is it important?

The novel acridine derivatives may be inhibitors for P-glycoprotein, serving as MDR-reversing agents.

Perspectives

These acridine derivatives may further be applied as novel MDR-reversing agents.

Professor Jianhong Wang
Key laboratory of natural medicines and immuno-engineering for Henan province

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This page is a summary of: Synthesis, Structure-Activity Relationship and Biological Activity of Acridine Derivatives as Potent MDR-Reversing Agents, Current Medicinal Chemistry, September 2013, Bentham Science Publishers,
DOI: 10.2174/09298673113209990187.
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