What is it about?

This review summarizes the neurotransmitter and neuropeptide alterations in the brainstem and hippocampus in major depression. This review suggests a multimodal antidepressant pharmacotherapy.

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Why is it important?

The interaction between presynaptic inhibitory and postsynaptic neurotransmitters is of importance and is included in the description of neural networks

Perspectives

A mulitmodal pharmacotherapy in major depression can enhance the antidepressant effect. GABAB antagonists can be combined with selective noradrenaline reuptake inhibitors.

Dr Felix-Martin Werner
Euro Akademie Pößneck

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This page is a summary of: Classical Neurotransmitters and Neuropeptides Involved in Major Depression in a Multi-neurotransmitter System: A Focus on Antidepressant Drugs, Current Medicinal Chemistry, November 2013, Bentham Science Publishers,
DOI: 10.2174/09298673113206660280.
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