What is it about?
Cellular model of neurodegeneration is created and studied, showing the consequences of the decreased ketoglutarate dehydrogenase activity, observed in post-mortem brain of patients with the Alzheimer and Parkinson diseases
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Why is it important?
The study reveals what occurs in neurons with the ketoglutarate dehydrogenase function decreased and why the inhibition may cause the neurodegeneration
Perspectives
We can better treat the neurodegenerative diseases when we know the underlying molecular mechanisms. For example, the study indicates why thiamine supplementation is beneficial in these diseases.
Prof Victoria I Bunik
Belozersky Institute of Moscow Lomonosov State University
Read the Original
This page is a summary of: Consequences of the α-Ketoglutarate Dehydrogenase Inhibition for Neuronal Metabolism and Survival: Implications for Neurodegenerative Diseases, Current Medicinal Chemistry, November 2012, Bentham Science Publishers,
DOI: 10.2174/092986712804143367.
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